| Aasha Encounter | 1 Jan 2022 | Anand Chandra | Srikanth Iyengar, Sonia Akula, Praveen Raj | |
| Induvadana | 1 Jan 2022 | M. Srinivas Raju | Varun Sandesh, Farnaz Shetty, Raghu Babu, Dhanraj | |
| 1945 | 7 Jan 2022 | Sathyasiva | Rana Daggubati, Regina Cassandra, Sathyaraj, Nassar | |
| Atithi Devo Bhava | 7 Jan 2022 | Polimera Nageshawar | Aadi, Nuveksha | |
| Bangarraju | 14 Jan 2022 | Kalyan Krishna | Nagarjuna, Naga Chaitanya, Ramya Krishna, Kriti Shetty | ₹66 cr |
| Rowdy Boys | 14 Jan 2022 | Harsha Konuganti | Ashish Reddy, Anupama Parameswaran | |
| Super Machi | 14 Jan 2022 | Puli Vaasu | Kalyan Dev, Rachita Ram | |
| The American Dream | 14 Jan 2022 | Dr. Vighnesh Koushik | Prince Cecil, Neha Krishna, Subhalekha Sudhakar | |
| Hero | 15 Jan 2022 | Sriram Adittya | Ashok Galla, Nidhhi Agerwal, Jagapathi Babu | ₹5 cr |
| Uniki | 18 Jan 2022 | Rajkumar Bobby | Chitra Shukla, Ashish Gandhi | |
| Good Luck Sakhi | 28 Jan 2022 | Nagesh Kukunoor | Keerthy Suresh, Aadhi Pinisetty, Jagapathi Babu, Rahul Ramakrishna | |
| Bhamakalapam | 11 Feb 2022 | Abhimanyu | Priyamani, Saranya Pradeep | |
| Khiladi | 11 Feb 2022 | Ramesh Varma | Ravi Teja, Arjun Sarja, Unni Mukundan, Meenakshi Chaudhary | |
| Malli Modalaindhi | 11 Feb 2022 | TG Keerthi Kumar | Sumanth, Naina Ganguly, Varshini Sounderajan, Pavani Reddy | |
| Sehari | 11 Feb 2022 | Gnanasagar Dwaraka | Harsh Kanumilli, Simran Choudhary, Abhinav Gomatam, Praneeth Reddy Kallem | |
| DJ Tillu | 12 Feb 2022 | Vimal Krishna | Siddhu Jonnalagadda, Neha Shetty | ₹30 cr |
| Son of India | 18 Feb 2022 | Diamond Ratnababu | Mohan Babu, Srikanth, Tanikella Bharani, Ali | |
| Virgin Story | 18 Feb 2022 | Pradip B. Atluri | Vikram Sahadev, Sowmika Pandiyan, Rishika Khanna | |
| Bheemla Nayak | 25 Feb 2022 | Saagar K Chandra | Pawan Kalyan, Rana Daggubati, Nithya Menen, Samyuktha Menon | ₹158 cr |
| Aadavallu Meeku Johaarlu | 4 Mar 2022 | Tirumala Kishore | Sharwanand, Rashmika Mandanna, Kushboo, Radhika Sarathkumar | |
| Sebastian PC 524 | 4 Mar 2022 | Balaji Sayyapureddy | Kiran Abbavaram, Komalee Prasad, Nuveksha | |
| Radhe Shyam | 11 Mar 2022 | Radha Krishna Kumar | Prabhas, Pooja Hegde, Krishnam Raju, Sachin Khedekar | ₹140 cr |
| Stand Up Rahul | 18 Mar 2022 | Santo | Raj Tarun, Varsha Bollamma, Murali Sharma, Indraja | |
| RRR | 25 Mar 2022 | S. S. Rajamouli | N. T. Rama Rao Jr, Ram Charan, Ajay Devgn, Alia Bhatt | ₹1,230 cr |
| Mishan Impossible | 1 Apr 2022 | Swaroop RSJ | Taapsee Pannu, Harsh Roshan, Bhanu Prakshan, Jayateertha Molugu | |
| Ghani | 8 Apr 2022 | Kiran Korrapati | Varun Tej, Jagapathi Babu, Saiee Manjrekar, Upendra | ₹21 cr |
| Bloody Mary | 15 Apr 2022 | Chandoo Mondeti | Nivetha Pethuraj, Brahmaji, Ajay, Kireeti Damaraju | |
| Zinga | 19 Apr 2022 | Jaichanakar Chigurula | Sanjeev Devan, Sripriya, Sriram, Kasu Naveen Kumar | |
| Bommala Koluvu | 22 Apr 2022 | Swaroop RSJ | Hrishikesh, Priyanka Sharma, Malavika Satheesan, Subbu Vedula | |
| Acharya | 29 Apr 2022 | Koratala Siva | Chiranjeevi, Ram Charan, Pooja Hegde, Sonu Sood | ₹74 cr |
| Ashoka Vanamlo Arjuna Kalyanam | 6 May 2022 | Vidya Sagar Chinta | Vishwak Sen, Rukshar Dhillon, Ritika Nayak, Goparaju Ramana | |
| Bhala Thandanana | 6 May 2022 | Chaitanya Dantluri | Sree Vishnu, Catherine Tresa, Ramachandra Raju, Posani Krishna Murali | |
| Jayamma Panchayathi | 6 May 2022 | Vijay Kumar Kalivarapu | Suma Kanakala | |
| Sarkaru Vaari Paata | 12 May 2022 | Parasuram | Mahesh Babu, Keerthy Suresh, Samuthirakani, Vennela Kishore | ₹180 cr |
| Shekar | 20 May 2022 | Jeevitha | Rajasekhar, Athmiya Rajan, Muskaan Khubchandhani, Shivani Rajashekar | |
| F3: Fun and Frustration | 27 May 2022 | Anil Ravipudi | Venkatesh, Varun Tej, Tamannaah, Mehreen Pirzada | ₹134 cr |
| Major | 3 Jun 2022 | Sashi Kiran Tikka | Adivi Sesh, Sobhita Dhulipala, Saiee Manjrekar, Prakash Raj | |
| Ante Sundaraniki | 10 Jun 2022 | Vivek Athreya | Nani, Nazriya Nazim, Harsha Vardhan, Suhas Pagolu | ₹45 cr |
| Kinnerasani | 10 Jun 2022 | Ramana Teja | Kalyaan Dhev, Ann Sheetal, Ravindra Vijay | |
| Suraapanam | 10 Jun 2022 | Sampath Kumar | Sampath Kumar, Pragya Nayan, Ajay Ghosh, Fish Venkat | |
| Godse | 17 Jun 2022 | Gopi Ganesh Pattabhi | Satyadev, Aishwarya Lekshmi, Brahmaji, Tanikella Bharani | |
| Virata Parvam | 17 Jun 2022 | Venu Udugula | Sai Pallavi, Rana Daggubati, Priyamani, Nandita Das | ₹13 cr |
| Konda | 23 Jun 2022 | Ram Gopal Varma | Thrigun, Irra Mor, Tulasi, L. B. Sriram | |
| 7 Days 6 Nights | 24 Jun 2022 | M. S. Raju | Sumanth Ashwin, Meher Chahal, Rohan, Krithika Shetty | |
| Chor Bazaar | 24 Jun 2022 | B Jeeevan Reddy | Akash Puri, Gehana Sippy, Sunil, Posani Krishna Murali | |
| Gangster Gangaraju | 24 Jun 2022 | Eeshaan Suryaah | Laksh Chadalavada, Vedieka Dutt, Vennela Kishore, Charandeep | |
| Pellikuturu Party | 24 Jun 2022 | Aparna Malladi | Prince Cecil, Aneesha Dama, Bhavana Vazhapandal, Sai Ketan Rao | |
| Sadha Nannu Nadipe | 24 Jun 2022 | Lanka Pratheek Prem Karan | Lanka Pratheek Prem Karan, Vaishnavi Patwardhan, Nagendra Babu, Nassar | |
| Sammathame | 24 Jun 2022 | Gopinath Reddy | Kiran Abbavaram, Chandini Chowdary | |
| Chittam Maharani | 30 Jun 2022 | Akula Kasi Viswanath | Yazurved Gurram, Rachana Inder | |
| 10th Class Diaries | 1 Jul 2022 | Anji | Sriram, Avika Gor, Siva Balaji, Archana Shastry | |
| Pakka Commercial | 1 Jul 2022 | Maruthi | Gopichand, Raashi Khanna, Sathyaraj, Anasuya Bharadwaj | ₹15 cr |
| Shikaru | 1 Jul 2022 | Hari Kolagani | Sai Dhanshika, Tej Kurapati, Abhinav Medisetty, Dheeraj Aathreya | |
| October–December | 8 Jul 2022 | Ritesh Rana | Lavanya Tripathi, Vennela Kishore | |
| The Warriorr | 14 Jul 2022 | N. Lingusamy | Ram Pothineni, Aadhi Pinisetty, Krithi Shetty, Akshara Gowda | ₹37 cr |
| Thank You | 22 Jul 2022 | Vikram Kumar | Naga Chaitanya, Raashi Khanna, Avika Gor, Malavika Nair | ₹9 cr |
| Ramarao on Duty | 29 Jul 2022 | Sarath Mandava | Ravi Teja, Divyansha Kaushik, Rajisha Vijayan, Venu Thottempudi | |
| Bimbisara | 5 Aug 2022 | Mallidi Vashist | Nandamuri Kalyan Ram, Catherine Tresa, Samyuktha Menon, Warina Hussain | ₹65 cr |
| Sita Ramam | 5 Aug 2022 | Hanu Raghavapudi | Dulquer Salmaan, Mrunal Thakur, Rashmika Mandanna, Sumanth | ₹94 cr |
| Macherla Niyojakavargam | 12 Aug 2022 | S. Raja Shekhar Reddy | Nithiin, Krithi Shetty, Catherine Tresa, Samuthirakani | ₹16 cr |
| Karthikeya 2 | 13 Aug 2022 | Chandoo Mondeti | Nikhil Siddharth, Anupama Parameswaran, Anupam Kher, Srinivas Reddy | ₹118 cr |
| Highway | 19 Aug 2022 | K. V. Guhan | Saiyami Kher, John Vijay, Satya | |
| Tees Maar Khan | 19 Aug 2022 | Kalyanji Gogana | Aadi Sai Kumar, Payal Rajput, Sunil, Poorna | |
| Wanted Pandugod | 19 Aug 2022 | Sreedhar Seepana | Sunil, Sudigali Sudheer, Deepika Pilli, Srinivasa Reddy | |
| Liger | 25 Aug 2022 | Puri Jagannadh | Vijay Deverakonda, Ananya Pandey, Mike Tyson, Ramya Krishnan | ₹61 cr |
| Odela Railway Station | 26 Aug 2022 | Ashok Teja | Hebah Patel, Pujita Ponnada, Vasishta N. Simha, Sai Ronak | |
| First Day First Show | 2 Sep 2022 | Vamshidhar Goud | Srikanth Reddy, Sanchita, Ali, Tanikella Bharani | |
| Ranga Ranga Vaibhavanga | 2 Sep 2022 | Gireesaaya | Panja Vaisshnav Tej, Ketika Sharma, Naveen Chandra, Ali | |
| Kotha Kothaga | 9 Sep 2022 | Hanumaan Vasamsetty | Ajay Aman, Virti Vaghani | |
| Oke Oka Jeevitham | 9 Sep 2022 | Shree Karthick | Sharwanand, Amala Akkineni, Ritu Varma, Vennela Kishore | ₹26 cr |
| Aa Ammayi Gurinchi Meeku Cheppali | 16 Sep 2022 | Mohana Krishna Indraganti | Sudheer Babu, Krithi Shetty, Vamsi Raghava Yenumula, Srinivas Avasarala | |
| Nenu Meeku Baaga Kavalsinavaadini | 16 Sep 2022 | Sridhar Gadhe | Kiran Abbavaram, Sanjana Anand, Sonu Thakur, Siddharth Menon | |
| Saakini Daakini | 16 Sep 2022 | Sudheer Varma | Nivetha Thomas, Regina Cassandra | |
| Alluri | 23 Sep 2022 | Pradeep Varma | Sree Vishnu, Kayadu Lohar, Tanikella Bharani, Suman | ₹8 cr |
| Dongalunnaru Jaagratha | 23 Sep 2022 | Satish Tripura | Sri Simha, Samuthirakani, Preethi Asrani | |
| Krishna Vrinda Vihari | 23 Sep 2022 | Anish R. Krishna | Naga Shaurya, Shirley Setia, Radhika Sarathkumar, Rahul Ramakrishna | ₹9 cr |
| Godfather | 5 Oct 2022 | Mohan Raja | Chiranjeevi, Salman Khan, Nayanthara, Satyadev | ₹109 cr |
| Swathi Muthyam | 5 Oct 2022 | Lakshman K Krishna | Bellamkonda Ganesh, Varsha Bollamma | |
| The Ghost | 5 Oct 2022 | Praveen Sattaru | Nagarjuna Akkineni, Sonal Chauhan, Gul Panag, Anikha Surendran | |
| Boyfriend for Hire | 14 Oct 2022 | Santosh Kambhampati | Viswant Duddumpudi, Malavika Satheesan, Harsha Vardhan, Madhunandan | |
| Ammu | 19 Oct 2022 | Charukesh Sekar | Aishwarya Lekshmi, Naveen Chandra, Bobby Simha, Raja Ravindra | |
| Ginna | 21 Oct 2022 | Suryaah | Vishnu Manchu, Payal Rajput, Sunny Leone, Sunil | ₹9 cr |
| Ori Devuda | 21 Oct 2022 | Ashwath Marimuthu | Vishwak Sen, Mithila Palkar, Venkatesh Daggubati, Asha Bhat | |
| Anukoni Prayanam | 28 Oct 2022 | Venkatesh Pediredla | Rajendra Prasad, Narasimha Raju, Prema, Tulasi | |
| Like, Share & Subscribe | 4 Nov 2022 | Merlapaka Gandhi | Santosh Sobhan, Faria Abdullah, Sudharshan, Brahmaji | |
| Urvasivo Rakshasivo | 4 Nov 2022 | Rakesh Sashii | Allu Sirish, Anu Emmanuel, Sunil, Aamani | |
| Pratibimbalu | 5 Nov 2022 | K. S. Prakash Rao, Singeetam Srinivasa Rao | Akkineni Nageswara Rao, Jayasudha, Tulasi | |
| Yashoda | 11 Nov 2022 | Hari–Harish | Samantha, Unni Mukundan, Varalaxmi Sarathkumar, Rao Ramesh | |
| Masooda | 18 Nov 2022 | Sai Kiran | Sangeetha, Thiruveer, Kavya Kalyan Ram, Subhalekha Sudhakar | ₹13 cr |
| Itlu Maredumilli Prajaneekam | 25 Nov 2022 | AR Mohan | Allari Naresh, Anandhi, Vennela Kishore, Praveen | |
| HIT: The Second Case | 2 Dec 2022 | Sailesh Kolanu | Adivi Sesh, Meenakshi Chaudhary, Suhas Pagolu, Rao Ramesh | ₹42 cr |
| Dangerous | 9 Dec 2022 | Ram Gopal Varma | Naina Ganguly, Apsara Rani, Rajpal Yadav | |
| Mukhachitram | 9 Dec 2022 | Sandeep Raj | Vikas Vasishta, Priya Vadlamani, Chaitanya Rao Madadi, Ayesha Khan | |
| Panchathantram | 9 Dec 2022 | Harsha Pulipaka | Brahmanandam, Swathi Reddy, Samuthirakani, Shivatmika Rajashekar | |
| Shasana Sabha | 16 Dec 2022 | | | |
| 18 Pages | 23 Dec 2022 | Palnati Surya Pratap | Nikhil Siddhartha, Anupama Parameswaran | ₹25 cr |
| Dhamaka | 23 Dec 2022 | Trinadha Rao Nakkina | Ravi Teja, Sree Leela, Jayaram, Sachin Khedekar | ₹82 cr |
| Lucky Lakshman | 30 Dec 2022 | AR Abhi | Syed Sohel, Mokksha, Devi Prasad, Raja Ravindra | |
| Nuvve Naa Pranam | 30 Dec 2022 | Srikrishna Malisetti | Kiran Raj, Priya Hedge | |
| Raajahyogam | 30 Dec 2022 | Ram Ganapathi | Sai Ronak, Ankita Saha, Bismi Naas, Ajay Ghosh | |
| S5 No Exit | 30 Dec 2022 | Sunny Komalapati | Taraka Ratna, P. Sai Kumar, Ali, Sunil | |
| Top Gear | 30 Dec 2022 | Shashikanth | Aadi Sai, Kumar, Riya Suman, Brahmaji | |
| Korameenu | 31 Dec 2022 | Sripathy Karri | Anand Ravi, Anveesha, Kishori Dhatrak | |