| 9 Jan 2021 | Krack | Gopichand Malineni | Ravi Teja, Shruti Haasan, Varalaxmi Sarathkumar, Samuthirakani | ₹71 cr |
| 12 Jan 2021 | Mail | Uday Gurrala | Priyadarshi Pulikonda, Harshith Malgireddy, Mani Aegurla, Gouripriya Reddy | |
| 14 Jan 2021 | Alludu Adhurs | Santhosh Srinivas | Bellamkonda Sreenivas, Nabha Natesh, Anu Emmanuel, Sonu Sood | |
| 14 Jan 2021 | Red | Kishore Tirumala | Ram Pothineni, Nivetha Pethuraj, Malvika Sharma, Amritha Aiyer | ₹36 cr |
| 15 Jan 2021 | Cycle | Aatla Arjun Reddy | Punarnavi Bhupalam, Mahat Raghavendra, Sudarshan, Swetha Varma | |
| 22 Jan 2021 | Super Over | Praveen Varma | Naveen Chandra, Chandini Chowdary, Ajay, Harsha Chemudu | |
| 23 Jan 2021 | Bangaru Bullodu | P. V. Giri | Allari Naresh, Pooja Jhaveri, Posani Krishna Murali, Ajay Ghosh | |
| 29 Jan 2021 | 30 Rojullo Preminchadam Ela | Munna | Pradeep Machiraju, Amritha Aiyer, Harsha Chemudu, Subhalekha Sudhakar | |
| 29 Jan 2021 | Amma Deevena | Shiva Eturi | Aamani, Posani Krishna Murali, Ajay Ghosh | |
| 29 Jan 2021 | Annapurnamma Gari Manavadu | Narra Shiva Nageswara Rao | Baladithya, Veda Sastry, Vikram Chary, Vijayendra | |
| 29 Jan 2021 | Cheppina Evaru Nammaru | Aaryan Krishna | Aaryan Krishna, Supyardee Singh, Vikram Chary, Vijayendra | |
| 29 Jan 2021 | Jai Sena | V. Samudra | Srikanth, Sunil, Sreeram, Taraka Ratna | |
| 29 Jan 2021 | Kalaposhakulu | Chalapathy Puvvula | Vishva Karthikeya, Deepa, Gemini Suresh, Ananth | |
| 29 Jan 2021 | Mr & Miss | Ashok Reddy | Sailesh Sunny, Gnaneswari Kandregula | |
| 4 Feb 2021 | Madhura Wines | Bandi Jayakishore | Naveen Kumar Reddy, Sahasra Reddy, Tumuluri Sammohit, Kommuri Leela Venkatesh | |
| 5 Feb 2021 | G- Zombie | Aryan, Deepu | Aryan Gowra, Divya Pandey | |
| 5 Feb 2021 | Pranavum | Kumar G | Sree Mangam, Avantika Hari, Gayatri Iyer, Gemini suresh | |
| 5 Feb 2021 | Zombie Reddy | Prasanth Varma | Sajja Teja, Anandhi, Harsha Vardhan, Raghu Babu | |
| 12 Feb 2021 | FCUK: Father Chitti Umaa Kaarthik | Vidya Sagar Raju | Jagapathi Babu, Ammu Abhirami, Ram Karthik, Baby Sahrashita | |
| 12 Feb 2021 | Uppena | Bucchi Babu Sana | Panja Vaisshnav Tej, Krithi Shetty, Vijay Sethupathi | ₹100 cr |
| 19 Feb 2021 | Kapatadhaari | Pradeep Krishnamoorthy | Sumanth, Nandita Swetha, Nassar, Jayaprakash | |
| 19 Feb 2021 | Naandhi | Vijay Kanakamedala | Allari Naresh, Varalaxmi Sarathkumar, Priyadarshi Pulikonda, Harish Uthaman | |
| 19 Feb 2021 | Pitta Kathalu | Nag Ashwin, B. V. Nandini Reddy | Shruti Haasan, Eesha Rebba, Amala Paul, Lakshmi Manchu | |
| 26 Feb 2021 | A: Ad Infitium | Ugandhar Muni | Nithin Prasanna, Preethi Asrani, Baby Deevena, Rangadam | |
| 26 Feb 2021 | Akshara | Chinni Krishna | Nandita Swetha, Ajay Ghosh, Shakalaka Shankar, K. Sivasankar | |
| 26 Feb 2021 | Check | Chandra Sekhar Yeleti | Nithiin, Rakul Preet Singh, Priya Prakash Varrier, Sampath Raj | |
| 26 Feb 2021 | Ninnila Ninnila | Ani I V Sasi | Ashok Selvan, Nithya Menon, Ritu Varma, Nassar | |
| 5 Mar 2021 | A1 Express | Dennis Jeevan Kanukolanu | Sundeep Kishan, Lavanya Tripathi, Rao Ramesh, Murali Sharma | |
| 5 Mar 2021 | April 28 Em Jarigindi | Veera Swamy | Raja Ranjith, Sherry Agarwal, Tanikella Bharani, Ajay | |
| 5 Mar 2021 | Play Back | Jakka Hari Prasad | Dinesh Tej, Spandana Palli, Ananya Nagalla, Arjun Kalyan | |
| 5 Mar 2021 | Power Play | Vijay Kumar Konda | Raj Tarun, Hemal Ingle, Shamna Kasim, Prince Cecil | |
| 5 Mar 2021 | Shaadi Mubarak | Padmasri | Sagar, Drushya Raghunath, Rahul Ramakrishna | |
| 11 Mar 2021 | Gaali Sampath | Anish Krishna | Sree Vishnu, Rajendra Prasad, Tanikella Bharani, Srikanth Aiyyangar | |
| 11 Mar 2021 | Jathi Ratnalu | Anudeep K V | Naveen Polishetty, Priyadarshi Pulikonda, Rahul Ramakrishna, Murali Sharma | ₹70 cr |
| 11 Mar 2021 | Sreekaram | Kishore Reddy | Sharwanand, Priyanka Mohan, Sai Kumar, Rao Ramesh | |
| 12 Mar 2021 | Love Life & Pakodi | Jayanth Gali | Bimal Kartheek Rebba, Sanchitha Poonacha, Krishna Hebbale, Anuradha Mallikarjun | |
| 19 Mar 2021 | Chaavu Kaburu Challaga | Koushik Pegallapati | Kartikeya Gummakonda, Lavanya Tripathi, Aamani, Srikanth Iyyengar | |
| 19 Mar 2021 | Mosagallu | Jeffrey Gee Chin | Vishnu Manchu, Kajal Aggarwal, Suniel Shetty, Ruhi Singh | |
| 19 Mar 2021 | Sashi | Nadikatla Srinivas Naidu | Aadhi Pudipeddi, Surbhi Puranik, Tulasi, Harsha Chemudu | |
| 26 Mar 2021 | Aranya | Prabhu Solomon | Rana Daggubati, Vishnu Vishal, Raghu Babu, Zoya Hussain | |
| 26 Mar 2021 | Rang De | Venky Atluri | Nithiin, Keerthy Suresh, Naresh, Kausalya | |
| 27 Mar 2021 | Thellavarithe Guruvaram | Manikanth Gelli | Sri Simha, Harsha Chemudu, Ajay, Ravi Varma | |
| 2 Apr 2021 | Wild Dog | Ashishor Solomon | Nagarjuna, Dia Mirza, Saiyami Kher | |
| 2 Apr 2021 | Y | Baalu Adusumilli | Sriram, Rahul Ramakrishna, Akshaya Chander, Gemini Suresh | |
| 9 Apr 2021 | Vakeel Saab | Venu Sriram | Pawan Kalyan, Anjali, Nivetha Thomas, Ananya Nagalla | ₹138 cr |
| 16 Apr 2021 | Deyyam | Ram Gopal Varma | Rajasekhar, Swathi Deekshith, Ahuti Prasad, Tanikella Bharani | |
| 7 May 2021 | Thank You Brother | Ramesh Rapathi | Anasuya Bharadwaj, Viraj Ashwin, Archana Ananth, Anish Kuruvilla | |
| 14 May 2021 | Battala Ramaswamy Biopikku | Rama Narayanan | Altaf Hassan, Lavanya Reddy, Satvika Jay, Shanthi Rao | |
| 14 May 2021 | Cinema Bandi | Praveen Kandregula | Vikas Vasishta, Sandeep Varanasi, Sindhu Sreenivasa Murthy, Sirivennela Yanamandhala | |
| 27 May 2021 | Ek Mini Katha | Karthik Rapolu | Santosh Shoban, Kavya Thapar, Shraddha Das, Posani Krishna Murali | |
| 11 Jun 2021 | Ardha Shathabdham | Rawindra Pulle | Karthik Rathnam, Naveen Chandra, Krishna Priya, Suhas | |
| 12 Jun 2021 | Pachchis | Sri Krishna, Rama Sai | Raamz, Swetaa Varma, Jay Chandra, Ravi Varma | |
| 9 Jul 2021 | Crrush | Ravi Babu | Krishna Burugula, Abhay Simha, Charan Sai, Ankita Manoj | |
| 20 Jul 2021 | Narappa | Srikanth Addala | Venkatesh, Priyamani, Karthik Rathnam, Rajeev Kanakala | |
| 30 Jul 2021 | Ishq | S. S. Raju | Sajja Teja, Priya Prakash Varrier | |
| 30 Jul 2021 | Thimmarusu | Sharan Koppisetty | Satyadev, Priyanka Jawalkar, Ajay, Brahmaji | |
| 6 Aug 2021 | MAD | Meneni Laxman | Rajath Raghav, Spandana Palli, Madhav Chilukuri, Swetha Varma | |
| 6 Aug 2021 | Merise Merise | Pawan Kumar K | Dinesh Tej, Shweta Avasthi, Sanjay Swarup, Guru Raj | |
| 6 Aug 2021 | Mugguru Monagallu | Abhilash reddy | Srinivasa Reddy, Dheekshith Shetty, Vennala Ramarao, Raja Ravindra | |
| 6 Aug 2021 | SR Kalyanamandapam | Sridhar Gade | Kiran Abbavaram, Priyanka Jawalkar, Sai Kumar, Anil Geela | |
| 14 Aug 2021 | Paagal | Naresh Kuppili | Vishwak Sen, Simran Choudary, Nivetha Pethuraj, Murali Sharma | |
| 19 Aug 2021 | Crazy Uncles | E Sathi Babu | Sreemukhi, Raja Ravindra, Mano, Bharani | |
| 19 Aug 2021 | Kanabadutaledu | Bala Raju M | Sunil, Vaishali Raj, Kancharapalem Raju, Sukranth Veerella | |
| 19 Aug 2021 | Raja Raja Chora | Hasith Goli | Sree Vishnu, Megha Akash, Sunaina, Ravi Babu | |
| 27 Aug 2021 | House Arrest | Shekher Reddy Erra | Srinivasa Reddy, Saptagiri, Adhurs Raghu, Ravi Prakash | |
| 27 Aug 2021 | Ichata Vahanamulu Niluparadu | S Darshan | Sushanth, Meenakshi Chaudhary, Vennela Kishore, Priyadarshi Pulikonda | |
| 27 Aug 2021 | Sridevi Soda Center | Karuna Kumar | Sudheer Babu, Anandhi, Naresh, Satyam Rajesh | |
| 27 Aug 2021 | Vivaha Bhojanambu | Ram Abbaraju | Satya, Sundeep Kishan, Aarjavee, Srikanth Iyyengar | |
| 3 Sep 2021 | Appudu - Ippudu | Chalapathi Puvvula | Sujan, Tanishq Ranjan | |
| 3 Sep 2021 | Asmee | Sesh Kartikeya | Rushika Raj, Raja Narendra, Keshav Deepakam, Indu Kusuma | |
| 3 Sep 2021 | Dear Megha | A. Sushanth Reddy | Megha Akash, Adith Arun, Arjun Somayajula, Pavitra Lokesh | |
| 3 Sep 2021 | Killer | Chinna | Karthik Sai, Daly Shah, Neha Deshpandey | |
| 3 Sep 2021 | Nootokka Jillala Andagadu | Rachakonda Vidyasagar | Avasarala Srinivas, Ruhani Sharma | |
| 10 Sep 2021 | Net | Bhargav Macharla | Rahul Ramakrishna, Avika Gor, Vishwadev Rachakonda, Praneeta Patnaik | |
| 10 Sep 2021 | Seetimaarr | Sampath Nandi | Gopichand, Tamannaah, Digangana Suryavanshi, Bhumika Chawla | |
| 10 Sep 2021 | Tuck Jagadish | Shiva Nirvana | Nani, Ritu Varma, Aishwarya Rajesh, Jagapathi Babu | |
| 17 Sep 2021 | Gully Rowdy | G. Nageswara Reddy | Sundeep Kishan, Neha Shetty, Bobby Simha, Harsha Chemudu | |
| 17 Sep 2021 | Maestro | Merlapaka Gandhi | Nithiin, Tamannaah, Nabha Natesh, Jisshu Sengupta | |
| 24 Sep 2021 | Aakashavaani | Ashwin Gangaraju | Samuthirakani, Vinay Varma, Teja Kakumanu, Prashant | |
| 24 Sep 2021 | Alanti Sitralu | Supreeth C Krishna | Shwetta Parashar, Prawin Yendamuri, Yash Puri, Tanvi Akaanksha | |
| 24 Sep 2021 | Love Story | Sekhar Kammula | Naga Chaitanya, Sai Pallavi, Rao Ramesh, Devayani | ₹62 cr |
| 24 Sep 2021 | Maro Prastanam | Johny | Tanish, Masskan Sethi, Kabir Dulhan Singh, Ravi Kale | |
| 1 Oct 2021 | Republic | Deva Katta | Sai Dharam Tej, Aishwarya Rajesh, Jagapathi Babu, Ramya Krishna | |
| 1 Oct 2021 | The Rose Villa | Hemanth | Dheekshith Shetty, Swetha Varma, Raja Ravindra | |
| 2 Oct 2021 | Idhe Maa Katha | Guru Pavan | Sumanth Ashwin, Srikanth, Bhumika Chawla, Tanya Hope | |
| 8 Oct 2021 | Aaradugula Bullet | B. Gopal | Gopichand, Nayanthara, Prakash Raj, Abhimanyu Singh | |
| 8 Oct 2021 | Itlu Amma | C. Umamaheswara Rao | MihiraVineethAruvi Bala | |
| 8 Oct 2021 | Konda Polam | Krish | Panja Vaisshnav Tej, Rakul Preet Singh, Sai Chand, Kota Srinivasa Rao | |
| 14 Oct 2021 | Maha Samudram | Ajay Bhupathi | Sharwanand, Siddharth, Aditi Rao Hydari, Anu Emmanuel | |
| 15 Oct 2021 | Most Eligible Bachelor | Bhaskar | Akhil Akkineni, Pooja Hegde, Eesha Rebba, Aamani | ₹51 cr |
| 15 Oct 2021 | Pelli SandaD | Gowri Ronanki | Roshan, Sree Leela, Rao Ramesh, Rajendra Prasad | |
| 22 Oct 2021 | Asalem Jarigandi | Nuleti Veera Raghava | Sriram, Sanchita Padukone | |
| 22 Oct 2021 | Heads and Tales | Sai Krishna Enreddy | Sunil, Srividya Maharshi, Divya Sripada, Chandni Rao | |
| 29 Oct 2021 | Family Drama | Meher Tej | Suhas, Teja Kasarapu, Sruti Meher | |
| 29 Oct 2021 | Romantic | Anil Paduri | Akash Puri, Ketika Sharma, Ramya Krishnan, Makarand Deshpande | |
| 29 Oct 2021 | Varudu Kaavalenu | Lakshmi Sowjanya | Naga Shaurya, Ritu Varma, Murali Sharma, Nadhiya | |
| 4 Nov 2021 | Manchi Rojulochaie | Maruthi | Santosh Sobhan, Mehreen Pirzada, Ajay Ghosh, Srinivasa Reddy | |
| 12 Nov 2021 | Pushpaka Vimanam | Damodara | Anand Deverakonda, Saanve Megghana, Geeth Saini, Sunil | |
| 12 Nov 2021 | Raja Vikramarka | Sri Saripalli | Kartikeya Gummakonda, Tanya Ravichandran, Sudhakar Komakula, Sai Kumar | |
| 19 Nov 2021 | Adbhutham | Mallik Ram | Teja Sajja, Shivani Rajashekar, Satya | |
| 25 Nov 2021 | Drushyam 2: The Resumption | Jeethu Joseph | Venkatesh, Meena, Kruthika Jayakumar, Esther Anil | |
| 26 Nov 2021 | 1997 | Dr. Mohan | Naveen Chandra, Dr. Mohan, Srikanth Iyengar | |
| 26 Nov 2021 | Anubhavinchu Raja | Sreenu Gavireddy | Raj Tarun, Kashish Khan, Posani Krishna Murali, Ajay | |
| 2 Dec 2021 | Akhanda | Boyapati Srinu | Nandamuri Balakrishna, Pragya Jaiswal, Jagapathi Babu, Srikanth | ₹150 cr |
| 4 Dec 2021 | Skylab | Vishavak Khanderao | Nithya Menen, Satyadev, Rahul Ramakrishna, Tanikella Bharani | |
| 10 Dec 2021 | Gamanam | Sujana Rao | Shriya Saran, Suhas, Priyanka Jawalkar, Siva Kandukuri | |
| 10 Dec 2021 | Lakshya | Dheerendra Santhossh Jagarlapudi | Naga Shaurya, Ketika Sharma, Jagapathi Babu, Sachin Khedekar | |
| 10 Dec 2021 | Sundarangudu | Vinay Babu | Krishna Sai, Mouryani, Isha, Mirchi Madhavi | |
| 17 Dec 2021 | Pushpa: The Rise | Sukumar | Allu Arjun, Fahadh Faasil, Rashmika Mandanna, Dhananjay | ₹350 cr |
| 24 Dec 2021 | Shyam Singha Roy | Rahul Sankrityan | Nani, Sai Pallavi, Krithi Shetty, Madonna Sebastian | |
| 24 Dec 2021 | WWW: Who Where Why | K. V. Guhan | Adith Arun, Shivani Rajashekar, Priyadarshi Pulikonda, Riyaz Khan | |
| 25 Dec 2021 | Gudaputani | KM Kumar | Saptagiri, Raghu Kunche, Ananth | |
| 31 Dec 2021 | Arjuna Phalguna | Teja Marni | Sree Vishnu, Naresh, Sivaji Raja, Subbaraju | |
| 31 Dec 2021 | Senapathi | Pavan Sadineni | Rajendra Prasad, Naresh Agastya, Harsha Vardhan, Gnaneswari Kandregula | |