| Maa Nanna Chiranjeevi | 1 Jan 2010 | Arun Prasad | Jagapati Babu, Neelima, Athulith, Brahmanandam | |
| Premistu | 1 Jan 2010 | Raghavendra | Ramana, Swathi | |
| Yugalageetham | 1 Jan 2010 | Sivaji | Srikar, Abhishek, Chandu | |
| Om Shanti | 10 Jan 2010 | Prakash Dantuluri | Navdeep, Kajal Aggarwal | |
| Adhurs | 13 Jan 2010 | V. V. Vinayak | NTR Jr, Nayantara, Sheela, Mahesh Manjrekar | ₹28 cr |
| Namo Venkatesa | 14 Jan 2010 | Seenu Vytla | Venkatesh, Trisha Krishnan, Brahmanandam | |
| Shambo Shiva Shambo | 14 Jan 2010 | Samudrakani | Ravi Teja, Allari Naresh, Siva Balaji, Priyamani | |
| Kaluva | 22 Jan 2010 | M. Sridhar | Chakri, Rupa Kaur, Fharzana | |
| Seeta Ramula Kalyanam Lankalo | 22 Jan 2010 | Eshwar | Nitin, Hansika Motwani, Brahmanandam | |
| Udatha Udatha Ooch | 22 Jan 2010 | Murali Ganesh | Sunil-Lee Akshay, Ali, Brahmanandam | |
| Bindaas | 5 Feb 2010 | Veeru Potla | Manoj Manchu, Sheena Shahabadi | |
| Kedi | 12 Feb 2010 | Kiran Kumar | Nagarjuna, Mamta Mohandas, Chitrangada Singh | |
| Joy | 19 Feb 2010 | B. R. Varma | Avitej, Trinath, Vainavi, Parvati | |
| Leader | 19 Feb 2010 | Sekhar Kammula | Rana Daggubati, Richa Gangopadhyay, Priya Anand | |
| Kalavar King | 20 Feb 2010 | Suresh | Nikhil Siddharth, Shweta Prasad, Ali, Ajay | |
| Inkosaari | 26 Feb 2010 | Suman Pathuri | Raja, Manjari Phadnis, Richa Pallod | |
| Ye Maaya Chesave | 26 Feb 2010 | Gautham Vasudev Menon | Naga Chaitanya, Samantha Ruth Prabhu, Krishnudu | |
| High School | 5 Mar 2010 | Narasimha Nandi | Kiran Rathod, Karthik | |
| Sadhyam | 5 Mar 2010 | Karthikeya Gopalakrishna | Jagapati Babu, Priyamani | |
| Aakasa Ramanna | 12 Mar 2010 | G. Ashok | Allari Naresh, Sivaji, Rajiv Kanakala | |
| Dasanna | 12 Mar 2010 | DSP | Srihari, Meena, Suman | |
| Prema Rajyam | 12 Mar 2010 | Moolapati | Ramkiran, Meerakrishna | |
| Tik Tik Tik | 12 Mar 2010 | Arunakanth | Krishna Bhagawan, Sairabanu, Sharif | |
| Sandadi | 19 Mar 2010 | Mani | Sasi Pawan, Suhasini, Keerthi | |
| Yagam | 19 Mar 2010 | P. A. Arun Prasad | Navdeep, Bhoomika Chawla, Kim Sharma | |
| Taj Mahal | 20 Mar 2010 | Arun Singaraju | Sivaji, Shruthi | |
| Maro Charitra | 26 Mar 2010 | Ravi Yadav | Varun Sandesh, Anita Galler, Shraddha Das | |
| My Name is Amrutha | 26 Mar 2010 | M. Anthony | Baby Gayathri, Bhanupriya, Bhanuchander | |
| Varudu | 31 Mar 2010 | Gunasekhar | Allu Arjun, Arya, Bhanu Mehra | |
| Anaganaga Oka Aranyam | 2 Apr 2010 | G. Shekar Chandra | Kaushal, Ekta Trivedi, Srirekha | |
| Srimathi Kalyanam | 2 Apr 2010 | Sival | Vadde Naveen, Sangeetha, Venu Madhav | |
| Betting Bangarraju | 9 Apr 2010 | Satti Babu | Allari Naresh, Nidhi | |
| Mouna Ragam | 9 Apr 2010 | Vijay Balaji | Tanish, Madhuurima, Suhasini | |
| Police Police | 9 Apr 2010 | Manmohan | Prithviraj, Sriram, Kamalini Mukherjee, Sanjana | |
| 1940 Lo Oka Gramam | 16 Apr 2010 | Narasimha Nandi | Bala Aditya, Shree | |
| Madhanudu | 16 Apr 2010 | Joe | Swati Rachana, Aarmugam | |
| Prasthanam | 16 Apr 2010 | Deva Katta | Sharwanand, Sai Kumar, Sundeep Kishan | |
| Darling | 23 Apr 2010 | Karunakaran | Prabhas, Kajal Aggarwal, Shraddha Das | ₹36 cr |
| Buridi | 30 Apr 2010 | E. V. V. Satyanarayana | Aryan Rajesh, Aishwarya | |
| Glamour | 30 Apr 2010 | P. Satya Reddy | Karishma Kotak, Kavitha | |
| Simha | 30 Apr 2010 | Boyapati Srinu | Balakrishna, Nayantara, Sneha Ullal, Namitha | ₹60 cr |
| Andari Bandhuvaya | 14 May 2010 | Chandra Siddhartha | Sharwanand, Padmapriya, Naresh | |
| Rama Rama Krishna Krishna | 14 May 2010 | | Ram, Arjun, Priya Anand, Bindu Madhavi | |
| Young India | 14 May 2010 | Dasari Narayana Rao | Pradyumna, Arvind Krishna, Soumya Bollapragada | |
| Chalaki | 21 May 2010 | | Aditya Babu, Roma Asrani, Bianca Desai | |
| Golimaar | 28 May 2010 | Puri Jagannadh | Gopichand, Priyamani, Nassar | |
| Vedam | 4 Jun 2010 | Radhakrishna Jagarlamudi | Allu Arjun, Anushka Shetty, Manoj Manchu, Manoj Bajpayee | |
| Nagamani | 11 Jun 2010 | | Krishna Bhagawan, Sona | |
| Panchakshari | 11 Jun 2010 | | Anushka Shetty, Vijay Samrat, Bramanandam | |
| Pappu | 25 Jun 2010 | | Krishnudu, Subbaraju, Deepika | |
| Jhummandi Naadam | 2 Jul 2010 | Raghavendra Rao | Manoj Manchu, Taapsee Pannu, Mohan Babu | |
| Komaram Bheem | 2 Jul 2010 | | Bhopal Reddy, Maunika, Telangana Sakuntala | |
| Bheemili Kabaddi Jattu | 9 Jul 2010 | | Nani, Saranya Mohan, Kishoreu | |
| Veera Telangana | 9 Jul 2010 | Narayana Murthy | R. Narayana Murthy, Vijayaranga Raju | |
| Em Pillo Em Pillado | 16 Jul 2010 | Chowdary | Tanish, Pranitha, Charanraj | |
| Shubhapradham | 16 Jul 2010 | K. Viswanath | Allari Naresh, Manjari Phadnis, Sarath Babu | |
| Sneha Geetham | 16 Jul 2010 | Madhura Sreedhar | Chitralekha, Anil, Gundu Hanumantha Rao | |
| Maryada Ramanna | 23 Jul 2010 | S. S. Rajamouli | Sunil, Saloni Aswani, Nagineedu | ₹52 cr |
| Comedy Express | 30 Jul 2010 | | Kaushal, Babu Mohan, Rajesh | |
| Maa Annayya Bangaram | 30 Jul 2010 | Jonnalagadda Srinivas | Rajasekhar, Kamalinee Mukherjee, Rohit | |
| Don Seenu | 6 Aug 2010 | Gopichand | Ravi Teja, Shriya Saran, Anjana Sukhani, Srihari | |
| Sye Aata | 13 Aug 2010 | | Charmi, Ajay, Rao Ramesh | |
| Happy Happy Ga | 20 Aug 2010 | | Varun Sandesh, Vega Tamotia, Saranya Mohan, P. Ravi Shankar | |
| Ramdev | 20 Aug 2010 | | Abbas, Sai Kiran, Gracy Singh | |
| Aunty Uncle Nandagopal | 27 Aug 2010 | | Vadde Naveen, Lakshana, Bramhanandam | |
| Gudu Gudu Gunjam | 27 Aug 2010 | | Parthu, Aarthi Puri, Rajendra Prasad | |
| Gaayam 2 | 3 Sep 2010 | | Jagapati Babu, Vimala Raman, Kota Srinivasa Rao | |
| Thakita Thakita | 3 Sep 2010 | | Harsh Vardhan Rane, Haripriya, Vijay Samrat, Trinetrudu | |
| Puli | 10 Sep 2010 | S. J. Surya | Pawan Kalyan, Nikesha Patel, Manoj Bajpayee | ₹19 cr |
| Bhairava IPS | 17 Sep 2010 | | Srihari, Sindhu Tolani, Tanikella Bharani | |
| Saradagaa Kasepu | 17 Sep 2010 | Vamsi | Allari Naresh, Madhurima, Srinivas Avasarala | |
| Khaleja | 8 Oct 2010 | Trivikram Srinivas | Mahesh Babu, Anushka Shetty, Prakash Raj | ₹32 cr |
| Brindavanam | 15 Oct 2010 | Vamsi Paidipally | NTR Jr, Kajal Aggarwal, Samantha | ₹35 cr |
| Rakta Charitra | 22 Oct 2010 | Ram Gopal Varma | Vivek Oberoi, Sudeep, Radhika Apte | |
| Brahmalokam To Yamalokam Via Bhulokam | 29 Oct 2010 | | Rajendra Prasad, Shivaji, Kalyani | |
| Collector Gari Bharya | 5 Nov 2010 | | Prakash Raj, Bhumika Chawla | |
| Kalyanram Kathi | 12 Nov 2010 | | Kalyan Ram, Shaam, Sana Khan, Saranya Mohan | |
| Yemaindi Ee Vela | 12 Nov 2010 | Sampath Nandi | Varun Sandesh, Nisha Aggarwal | |
| Karma | 26 Nov 2010 | Adivi Sesh | Adivi Sesh, Jade Tailor, Sher Ali | |
| Orange | 26 Nov 2010 | Bhaskar | Ram Charan Teja, Genelia D'Souza, Shazahn Padamsee | ₹20 cr |
| Aalasyam Amrutam | 3 Dec 2010 | | Nikhil Siddharth, Madhurima, Arvind Krishna | |
| Rakta Charitra 2 | 3 Dec 2010 | Ram Gopal Varma | Vivek Oberoi, Sudeep, Radhika Apte | |
| Kathi Kantha Rao | 10 Dec 2010 | E. V. V. Satyanarayana | Allari Naresh, Kamna Jethmalani, Krishna Bhagawan | |
| Manasara | 10 Dec 2010 | Ravi Babu | Vikram, Sri Divya | |
| Nagavalli | 16 Dec 2010 | P. Vasu | Venkatesh, Anushka Shetty, Richa Gangopadhyay, Shraddha Das | ₹17 cr |
| Ragada | 24 Dec 2010 | Veeru Potla | Nagarjuna, Anushka Shetty, Priyamani | ₹30 cr |
| Ranga The Donga | 30 Dec 2010 | G. V. Sudhakar Naidu | Srikanth, Vimala Raman, Ramya Krishna | |
| Broker | 31 Dec 2010 | R. P. Patnaik | R. P. Patnaik, Srihari, Asha Saini | |